货号：GZ9393
TRPV4;VRL2;VROAC;Transient receptor potential cation channel subfamily V member 4;TrpV4;Osm-9-like TRP channel 4;OTRPC4;Transient receptor potential protein 12;TRP12;Vanilloid receptor-like channel 2;Vanilloid receptor-like protein 2;VRL-2;Vanilloid receptor-related osmotically-activated channel;VR-OAC
| 别名 | TRPV4;VRL2;VROAC;Transient receptor potential cation channel subfamily V member 4;TrpV4;Osm-9-like TRP channel 4;OTRPC4;Transient receptor potential protein 12;TRP12;Vanilloid receptor-like channel 2;Vanilloid receptor-like protein 2;VRL-2;Vanilloid receptor-related osmotically-activated channel;VR-OAC |
| 基因名称 | TRPV4 |
| 蛋白名称 | Transient receptor potential cation channel subfamily V member 4 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q9HBA0 |
| Mouse Gene ID | 63873 |
| Mouse Swissprot No. | Q9EPK8 |
| Rat Gene ID | 66026 |
| Rat Swissprot No. | Q9ERZ8 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000-1:5000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | 90-100kDa |
| 预测分子量 | 98kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | transient receptor potential cation channel subfamily V member 4(TRPV4) Homo sapiens This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010], |
| 细胞定位 | Cell membrane . Apical cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. .; [Isoform 1]: Cell membrane .; [Isoform 5]: Cell membrane .; [Isoform 2]: Endoplasmic reticulum .; [Isoform 4]: Endoplasmic reticulum .; [Isoform 6]: Endoplasmic reticulum . |
| 功能 | Disease:Defects in TRPV4 are the cause of brachyolmia type 3 [MIM:113500]; also called brachyrachia. The brachyolmias constitute a clinically and genetically heterogeneous group of skeletal dysplasias characterized by a short trunk, scoliosis and mild short stature. Type 3 brachyolmia is an autosomal dominant form with severe kyphoscoliosis and flattened, irregular cervical vertebrae.,Function:Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 3 ANK repeats.,subcellular location:Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.,subunit:Homotetramer (Probable). Self-associates in a isoform-specific manner. Isoforms 1/A and 5/D but not isoform 2/B, 4/C and 6/E can oligomerize. Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES., |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane . Apical cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. .; [Isoform 1]: Cell membrane .; [Isoform 5]: Cell membrane .; [Isoform 2]: Endoplasmic reticulum .; [Isoform 4]: Endoplasmic reticulum .; [Isoform 6]: Endoplasmic reticulum . |
周一至周日 8:00-18:00
