| 别名 | CAMK2D;CAMKD;Calcium/calmodulin-dependent protein kinase type II subunit delta;CaM kinase II subunit delta;CaMK-II subunit delta |
| 基因名称 | CAMK2D |
| 蛋白名称 | Calcium/calmodulin-dependent protein kinase type II subunit delta |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q13557 |
| Mouse Gene ID | 108058 |
| Mouse Swissprot No. | Q6PHZ2 |
| Rat Gene ID | 24246 |
| Rat Swissprot No. | P15791 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 55kDa |
| 预测分子量 | 56kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008], |
| 细胞定位 | Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,miscellaneous:Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,tissue specificity:Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle., |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . |
周一至周日 8:00-18:00
