货号：GZ9361
Peroxiredoxin-6;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein;Acidic calcium-independent phospholipase A2;aiPLA2;Antioxidant protein 2;Liver 2D page spot 40;Non-selenium glutathione peroxidase;NSGPx;Red blood cells page spot 12;AOP2;KIAA0106
| 别名 | Peroxiredoxin-6;1-Cys peroxiredoxin;1-Cys PRX;24 kDa protein;Acidic calcium-independent phospholipase A2;aiPLA2;Antioxidant protein 2;Liver 2D page spot 40;Non-selenium glutathione peroxidase;NSGPx;Red blood cells page spot 12;AOP2;KIAA0106 |
| 基因名称 | PRDX6 |
| 蛋白名称 | Peroxiredoxin-6 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P30041 |
| Mouse Swissprot No. | O08709 |
| Rat Swissprot No. | O35244 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 25kDa |
| 预测分子量 | 25kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm . Lysosome . Also found in lung secretory organelles (lamellar bodies). . |
| 功能 | Catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,Catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,Function:Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.,miscellaneous:Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.,miscellaneous:The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.,similarity:Belongs to the ahpC/TSA family. Rehydrin subfamily.,similarity:Contains 1 thioredoxin domain.,subcellular location:And also found in lung secretory organelles.,subunit:Homotetramer. May interact with HTR2A (By similarity). Interacts with STH., |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Lysosome . Also found in lung secretory organelles (lamellar bodies). . |
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