| 别名 | FOLR1;FOLR;Folate receptor alpha;FR-alpha;Adult folate-binding protein;FBP;Folate receptor 1;Folate receptor;adult;KB cells FBP;Ovarian tumor-associated antigen MOv18 |
| 基因名称 | FOLR1 |
| 蛋白名称 | Folate receptor alpha |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P15328 |
| Mouse Swissprot No. | P35846 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:500;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 35kDa |
| 预测分子量 | 30kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009], |
| 细胞定位 | Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. . |
| 功能 | Function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.,PTM:Eight disulfide bonds are present.,PTM:The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.,similarity:Belongs to the folate receptor family.,tissue specificity:Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum., |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane ; Lipid-anchor, GPI-anchor . Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. . |
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