| 别名 | SPARC;ON;SPARC;Basement-membrane protein 40;BM-40;Osteonectin;ON;Secreted protein acidic and rich in cysteine |
| 基因名称 | SPARC |
| 蛋白名称 | SPARC |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P09486 |
| Mouse Gene ID | 20692 |
| Mouse Swissprot No. | P07214 |
| Rat Gene ID | 24791 |
| Rat Swissprot No. | P16975 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:500;WB 1:1000-1:5000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 39kDa |
| 预测分子量 | 35kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015], |
| 细胞定位 | Secreted, extracellular space, extracellular matrix, basement membrane . In or around the basement membrane. |
| 功能 | developmental stage:Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.,Function:Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.,online information:Osteonectin entry,similarity:Belongs to the SPARC family.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 follistatin-like domain.,similarity:Contains 1 Kazal-like domain.,subcellular location:In or around the basement membrane., |
| Clonality | Monoclonal |
| 细胞定位 | Secreted, extracellular space, extracellular matrix, basement membrane . In or around the basement membrane. |
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