货号：GZ9346
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1;Lipid raft adaptor protein p18;Protein associated with DRMs and endosomes;p27Kip1-releasing factor from RhoA;p27RF-Rho;C11orf59;PDRO;PP7157
| 别名 | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1;Lipid raft adaptor protein p18;Protein associated with DRMs and endosomes;p27Kip1-releasing factor from RhoA;p27RF-Rho;C11orf59;PDRO;PP7157 |
| 基因名称 | LAMTOR1 |
| 蛋白名称 | Ragulator complex protein LAMTOR1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q6IAA8 |
| Mouse Gene ID | 66508 |
| Mouse Swissprot No. | Q9CQ22 |
| Rat Gene ID | 308869 |
| Rat Swissprot No. | Q6P791 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | 18kDa |
| 预测分子量 | 18kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Enables GTPase binding activity and protein-membrane adaptor activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of TORC1 signaling; and regulation of cholesterol transport. Located in lysosome. Part of FNIP-folliculin RagC/D GAP. Is active in Ragulator complex and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2025] |
| 细胞定位 | ysosome membrane; Lipid-anchor Late endosome membrane; Lipid-anchor Note: Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. |
| 功能 | Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:29158492). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it 1 acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and 2 mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:28935770, PubMed:29158492, PubMed:30181260, PubMed:31001086, PubMed:32686708, PubMed:36476874). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:20381137, PubMed:22980980, PubMed:29158492). LAMTOR1 is directly responsible for anchoring the Ragulator complex to the lysosomal membrane (PubMed:31001086, PubMed:32686708). LAMTOR1 wraps around the other subunits of the Ragulator complex to hold them in place and interacts with the Rag GTPases, thereby playing a key role in the recruitment of the mTORC1 complex to lysosomes (PubMed:28935770, PubMed:29107538, PubMed:29123114, PubMed:29285400). Also involved in the control of embryonic stem cells differentiation via non-canonical RagC/RRAGC and RagD/RRAGD activation: together with FLCN, it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes (PubMed:20381137, PubMed:22980980). May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes (PubMed:20544018). May also play a role in RHOA activation (PubMed:19654316). |
| Clonality | Monoclonal |
| 细胞定位 | ysosome membrane; Lipid-anchor Late endosome membrane; Lipid-anchor Note: Recruited to lysosome and endosome membranes through N-terminal myristoylation and palmitoylation. |
周一至周日 8:00-18:00
