| 别名 | UTX |
| 基因名称 | KDM6A |
| 蛋白名称 | Lysine-specific demethylase 6A (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O15550 |
| Mouse Gene ID | 22289 |
| Mouse Swissprot No. | O70546 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | 160kDa |
| 预测分子量 | 154kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 细胞定位 | Nucleus . |
| 功能 | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity). |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus . |
周一至周日 8:00-18:00
