| 别名 | MMH,MUTM,OGH1 |
| 基因名称 | OGG1 |
| 蛋白名称 | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase lyase (AP lyase) (EC 4.2.99.18)] |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O15527 |
| Mouse Swissprot No. | O08760 |
| Rat Swissprot No. | O70249 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000;WB 1:10000-1:50000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 39kDa |
| 预测分子量 | 39kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008], |
| 细胞定位 | Nucleus, nucleoplasm . Nucleus speckle . Nucleus matrix . Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; [Isoform 1A]: Nucleus.; [Isoform 2A]: Mitochondrion. |
| 功能 | Catalytic activity:The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.,Disease:Defects in OGG1 are a cause of renal cell carcinoma (RCC1) [MIM:144700].,Disease:Defects in OGG1 are associated with tumor formation.,Function:DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.,similarity:Belongs to the type-1 OGG1 family.,tissue specificity:Ubiquitous., |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus, nucleoplasm . Nucleus speckle . Nucleus matrix . Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; [Isoform 1A]: Nucleus.; [Isoform 2A]: Mitochondrion. |
周一至周日 8:00-18:00
