| 别名 | IVL;Involucrin |
| 基因名称 | IVL |
| 蛋白名称 | Involucrin |
| 推荐应用 | |
| 反应物种 | Human,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P07476 |
| Mouse Swissprot No. | P48997 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:1000-1:2000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000; |
| 参考分子量 | 118kDa |
| 预测分子量 | 68kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | involucrin(IVL) Homo sapiens Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm. Constituent of the scaffolding of the cornified envelope. |
| 功能 | Function:Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.,PTM:Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.,similarity:Belongs to the involucrin family.,subcellular location:Constituent of the scaffolding of the cornified envelope.,subunit:Directly or indirectly cross-linked to cornifelin (CNFN).,tissue specificity:Keratinocytes of epidermis and other stratified squamous epithelia., |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm. Constituent of the scaffolding of the cornified envelope. |
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