Cytokeratin 6 (13D4) Rabbit Monoclonal Antibody-一抗-博克思生物科技

商品详情文献引用

别名	CK 6A;CK 6B;CK 6C;CK 6D;CK 6E;CK-6B;CK-6C;CK-6E;Cytokeratin 6a;Cytokeratin 6B;Cytokeratin 6C;Cytokeratin 6D;Cytokeratin 6E;Cytokeratin-6B;Cytokeratin-6C;Cytokeratin-6E;K2C6C_HUMAN;K6a keratin;K6b keratin;K6C;K6c keratin;K6d keratin;K6e keratin;Keratin;Keratin K6h;Keratin type II cytoskeletal 6A;Keratin type II cytoskeletal 6B;Keratin type II cytoskeletal 6C;Keratin type II cytoskeletal 6D;Keratin type II cytoskeletal 6E;Keratin-6C;KRT6A;KRT6B;KRT6C;KRT6D;KRT6E;type II cytoskeletal 6C;Type-II keratin Kb12
基因名称	KRT6A
蛋白名称	CK 6A;CK 6B;CK 6C;CK 6D;CK 6E;CK-6B;CK-6C;CK-6E;Cytokeratin 6a;Cytokeratin 6B;Cytokeratin 6C;Cytokeratin 6D;Cytokeratin 6E;Cytokeratin-6B;Cytokeratin-6C;Cytokeratin-6E;K2C6C_HUMAN;K6a keratin;K6b keratin;K6C;K6c keratin;K6d keratin;K6e keratin;Keratin;Keratin K6h;Keratin type II cytoskeletal 6A;Keratin type II cytoskeletal 6B;Keratin type II cytoskeletal 6C;Keratin type II cytoskeletal 6D;Keratin type II cytoskeletal 6E;Keratin-6C;KRT6A;KRT6B;KRT6C;KRT6D;KRT6E;type II cytoskeletal 6C;Type-II keratin Kb12
推荐应用
反应物种	Human,Mouse,Rat
存储缓冲液	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Human Swissprot No.	P48668
Mouse Swissprot No.	P50446
Rat Swissprot No.	Q4FZU2
特异性	Endogenous
稀释度	IHC-P 1:200-1:1000;WB 1:2000-1:10000;IF-P/IF-F/IF-ICC 1:200-1:1000;ELISA 1:5000-1:20000;
参考分子量	60kDa
预测分子量	60kDa
运输及保存条件	Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles
宿主	Rabbit
同种型	IgG,Kappa
背景介绍	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathoge
细胞定位	Cytoplasmic, Membranous
功能	allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,Disease:Defects in KRT6A are a cause of pachyonychia congenita type 1 (PC1) [MIM:167200]; also known as Jadassohn-Lewandowsky syndrome. PC1 is an autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.,miscellaneous:There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17. Interacts with TCHP.,tissue specificity:Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.,
Clonality	Monoclonal
细胞定位	Cytoplasmic, Membranous

Cytokeratin 6 (13D4) Rabbit Monoclonal Antibody

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