| 别名 | CLDN11;OSP;OTM;Claudin-11;Oligodendrocyte-specific protein |
| 基因名称 | CLDN11 |
| 蛋白名称 | Claudin-11 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O75508 |
| Mouse Gene ID | 18417 |
| Mouse Swissprot No. | Q60771 |
| Rat Swissprot No. | Q99P82 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 22kDa |
| 预测分子量 | 22kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso |
| 细胞定位 | Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein . |
| Clonality | Monoclonal |
| 细胞定位 | Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein . |
周一至周日 8:00-18:00
