| 别名 | GRIM12;KDRF |
| 基因名称 | TXNRD1 |
| 蛋白名称 | Thioredoxin reductase 1, cytoplasmic (TR) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q16881 |
| Mouse Swissprot No. | Q9JMH6 |
| Rat Swissprot No. | O89049 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 60kDa |
| 预测分子量 | 67kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | thioredoxin reductase 1(TXNRD1) Homo sapiens This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008], |
| 细胞定位 | [Isoform 1]: Cytoplasm .; [Isoform 4]: Cytoplasm . Nucleus .; [Isoform 5]: Cytoplasm . |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform 1]: Cytoplasm .; [Isoform 4]: Cytoplasm . Nucleus .; [Isoform 5]: Cytoplasm . |
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