| 别名 | IDE;Insulin-degrading enzyme;Abeta-degrading protease;Insulin protease;Insulinase;Insulysin |
| 基因名称 | IDE |
| 蛋白名称 | Insulin-degrading enzyme |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P14735 |
| Mouse Swissprot No. | Q9JHR7 |
| Rat Gene ID | 25700 |
| Rat Swissprot No. | P35559 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000, IF 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 118kDa |
| 预测分子量 | 118kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe |
| 细胞定位 | Cytoplasm, cytosol . Cell membrane . Secreted . Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm, cytosol . Cell membrane . Secreted . Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. |
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