| 别名 | UD11;GNT1;UGT1 |
| 基因名称 | UGT1A1 |
| 蛋白名称 | UDP-glucuronosyltransferase 1A1 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P22309 |
| Mouse Gene ID | 394436 |
| Mouse Swissprot No. | Q63886 |
| Rat Gene ID | 24861 |
| Rat Swissprot No. | Q64550 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:500-1:2000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 60kDa |
| 预测分子量 | 60kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm, perinuclear region . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Endoplasmic reticulum membrane ; Single-pass membrane protein . Cytoplasm, perinuclear region . |
周一至周日 8:00-18:00
