| 别名 | PIM1;Serine/threonine-protein kinase pim-1 |
| 基因名称 | PIM1 |
| 蛋白名称 | Serine/threonine-protein kinase pim-1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P11309 |
| Mouse Swissprot No. | P06803 |
| Rat Gene ID | 24649 |
| Rat Swissprot No. | P26794 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 34kDa |
| 预测分子量 | 45kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011], |
| 细胞定位 | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane. |
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