| 别名 | DAXX;BING2;DAP6;Death domain-associated protein 6;Daxx;hDaxx;ETS1-associated protein 1;EAP1;Fas death domain-associated protein |
| 基因名称 | DAXX |
| 蛋白名称 | Death domain-associated protein 6 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q9UER7 |
| Mouse Gene ID | 13163 |
| Mouse Swissprot No. | O35613 |
| Rat Swissprot No. | Q8VIB2 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:100-1:200, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 110kDa |
| 预测分子量 | 81kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript varian |
| 细胞定位 | Cytoplasm . Nucleus, nucleoplasm . Nucleus, PML body . Nucleus, nucleolus . Chromosome, centromere . Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383). .; [Isoform beta]: Nucleus . Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. .; [Isoform gamma]: Nucleus . Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Nucleus, nucleoplasm . Nucleus, PML body . Nucleus, nucleolus . Chromosome, centromere . Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli (Probable). Colocalizes with histone H3.3, ATRX, HIRA and ASF1A at PML-nuclear bodies (PubMed:12953102, PubMed:14990586, PubMed:23222847, PubMed:24200965). Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres (PubMed:9645950). Detected in cytoplasmic punctate structures (PubMed:11842083). Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress (PubMed:12968034). Colocalizes with RASSF1 in the nucleus (PubMed:18566590). Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures (PubMed:16845383). .; [Isoform beta]: Nucleus . Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. .; [Isoform gamma]: Nucleus . Diffuse nuclear distribution pattern and no comparable dot-like accumulation of isoform 1. . |
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