货号：GZ8969
IGF2BP3;IMP3;KOC1;VICKZ3;Insulin-like growth factor 2 mRNA-binding protein 3;IGF2 mRNA-binding protein 3;IMP-3;IGF-II mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer;hKOC;VICKZ family member 3
| 别名 | IGF2BP3;IMP3;KOC1;VICKZ3;Insulin-like growth factor 2 mRNA-binding protein 3;IGF2 mRNA-binding protein 3;IMP-3;IGF-II mRNA-binding protein 3;KH domain-containing protein overexpressed in cancer;hKOC;VICKZ family member 3 |
| 基因名称 | IGF2BP3 |
| 蛋白名称 | Insulin-like growth factor 2 mRNA-binding protein 3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | O00425 |
| Mouse Swissprot No. | Q9CPN8 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 64kDa |
| 预测分子量 | 64kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus. Cytoplasm. Cytoplasm, P-body . Cytoplasm, Stress granule . Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Nucleus. Cytoplasm. Cytoplasm, P-body . Cytoplasm, Stress granule . Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules. |
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