| 基因名称 | FCGR3A/FCGR2B |
| 蛋白名称 | Low affinity immunoglobulin gamma Fc region receptor III-A/Low affinity immunoglobulin gamma Fc region receptor II-b |
| 推荐应用 | |
| 反应物种 | Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Mouse Gene ID | 14130 |
| Mouse Swissprot No. | P08101;P08508 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 50-55kDa |
| 预测分子量 | 37,30kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Enables IgG binding activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; nervous system development; and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2A (Fc gamma receptor IIa) and FCGR2B (Fc gamma receptor IIb). [provided by Alliance of Genome Resources, Jul 2025] |
| 细胞定位 | Cell membrane ; Single-pass type I membrane protein;Isoform IIB1;Cytoplasm, cytoskeleton.[Note: Binds the cytoskeleton and is not localized in endocytotic pits];Isoform IIB3.Secreted.[Note: Released as a soluble molecule]. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Cell membrane ; Single-pass type I membrane protein;Isoform IIB1;Cytoplasm, cytoskeleton.[Note: Binds the cytoskeleton and is not localized in endocytotic pits];Isoform IIB3.Secreted.[Note: Released as a soluble molecule]. |
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