| 别名 | PRKAB1;AMPK;5'-AMP-activated protein kinase subunit beta-1;AMPK subunit beta-1;AMPKb |
| 基因名称 | PRKAB1 |
| 蛋白名称 | 5'-AMP-activated protein kinase subunit beta-1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q9Y478 |
| Mouse Gene ID | 19079 |
| Mouse Swissprot No. | Q9R078 |
| Rat Gene ID | 83803 |
| Rat Swissprot No. | P80386 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:100-1:500, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200, |
| 参考分子量 | 38kDa |
| 预测分子量 | 30kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided |
| 细胞定位 | nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
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