货号：GZ8721
IFIH1;MDA5;RH116;Interferon-induced helicase C domain-containing protein 1;Clinically amyopathic dermatomyositis autoantigen 140 kDa;CADM-140 autoantigen;Helicase with 2 CARD domains;Helicard;Interferon-induced with helicase C domai
| 别名 | IFIH1;MDA5;RH116;Interferon-induced helicase C domain-containing protein 1;Clinically amyopathic dermatomyositis autoantigen 140 kDa;CADM-140 autoantigen;Helicase with 2 CARD domains;Helicard;Interferon-induced with helicase C domai |
| 基因名称 | IFIH1 |
| 蛋白名称 | Interferon-induced helicase C domain-containing protein 1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q9BYX4 |
| Mouse Gene ID | 71586 |
| Mouse Swissprot No. | Q8R5F7 |
| 特异性 | Endogenous |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 135kDa |
| 预测分子量 | 117kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-depend |
| 细胞定位 | Cytoplasm . Nucleus . Mitochondrion . Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm . Nucleus . Mitochondrion . Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. |
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