| 别名 | ERBB3;HER3;Receptor tyrosine-protein kinase erbB-3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3 |
| 基因名称 | ERBB3 |
| 蛋白名称 | Receptor tyrosine-protein kinase erbB-3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P21860 |
| Mouse Gene ID | 13867 |
| Mouse Swissprot No. | Q61526 |
| Rat Gene ID | 29496 |
| Rat Swissprot No. | Q62799 |
| 特异性 | Phospho-ErbB-3 (Y1289) Monoclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1289.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QGyEE |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 185kDa |
| 预测分子量 | 148kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m |
| 细胞定位 | [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | [Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
周一至周日 8:00-18:00
