| 别名 | STAT6;Signal transducer and activator of transcription 6;IL-4 Stat |
| 基因名称 | STAT6 |
| 蛋白名称 | Signal transducer and activator of transcription 6 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P42226 |
| Mouse Gene ID | 20852 |
| Mouse Swissprot No. | P52633 |
| 特异性 | Phospho-Stat6 (Y641) Antibody detects endogenous levels of Stat6 protein only when phosphorylated at Y641.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGyVP |
| 稀释度 | IHC-P 1:500-1:2000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 110kDa |
| 预测分子量 | 94kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| 细胞定位 | Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 细胞定位 | Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
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