| 别名 | Transforming protein RhoA (Rho cDNA clone 12) (h12);ARH12;ARHA;RHO12 |
| 基因名称 | RHOA |
| 蛋白名称 | Rho A |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387 |
| Human Swissprot No. | P61586 |
| Human Swissprot Link | https://www.uniprot.org/uniprotkb/P61586/entry |
| Mouse Gene ID | 11848 |
| Mouse Gene Link | https://www.uniprot.org/uniprot/11848 |
| Mouse Swissprot No. | Q9QUI0 |
| Mouse Swissprot Link | https://www.uniprot.org/uniprotkb/Q9QUI0 |
| Rat Gene ID | 117273 |
| Rat Gene Link | https://www.uniprot.org/uniprot/117273 |
| Rat Swissprot No. | P61589 |
| Rat Swissprot Link | https://www.uniprot.org/uniprotkb/P61589 |
| 稀释度 | IHC-P 1:200-1000, WB 1:1000-5000, IF-P/IF-F/IF-ICC 1:200-1000, ELISA 1:5000-20000 |
| 参考分子量 | 21kDa |
| 预测分子量 | 21kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015], |
| 功能 | cofactor:Magnesium.,domain:The basic-rich region is essential for yopT recognition and cleavage.,function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP.,PTM:Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.,PTM:Substrate for botulinum ADP-ribosyltransferase.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:Interacts with RGNEF (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
周一至周日 8:00-18:00
