| 别名 | FIB1;FLRN |
| 基因名称 | FBL |
| 蛋白名称 | rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2091 |
| Human Swissprot No. | P22087 |
| Human Swissprot Link | https://www.uniprot.org/uniprot/P22087 |
| Mouse Gene ID | 100044829 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100044829 |
| Mouse Swissprot No. | P35550 |
| Mouse Swissprot Link | https://www.uniprot.org/uniprotkb/P35550/entry |
| Rat Gene ID | 292747 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=292747 |
| Rat Swissprot No. | P22509 |
| Rat Swissprot Link | https://www.uniprot.org/uniprotkb/P22509/entry |
| 稀释度 | IHC-P 1:200-1000, WB 1:1000-5000, IF-P/IF-F/IF-ICC 1:200-1000, ELISA 1:5000-20000 |
| 参考分子量 | 34kDa |
| 预测分子量 | 34kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 功能 | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
周一至周日 8:00-18:00
