| 别名 | GSK3B;Glycogen synthase kinase-3 beta;GSK-3 beta;Serine/threonine-protein kinase GSK3B |
| 基因名称 | GSK3B |
| 蛋白名称 | Glycogen synthase kinase-3 beta |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2932 |
| Human Swissprot No. | P49841 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P49841/entry |
| Mouse Gene ID | 56637 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56637 |
| Mouse Swissprot No. | Q9WV60 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/Q9WV60 |
| Rat Gene ID | 84027 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84027 |
| Rat Swissprot No. | P18266 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P18266 |
| 稀释度 | IHC-P 1:200-1000, WB 1:1000-5000, IF-P/IF-F/IF-ICC 1:200-1000, ELISA 1:5000-20000 |
| 参考分子量 | 46kDa |
| 预测分子量 | 46kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009], |
| 信号通路 | ErbB_HER;Chemokine;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;WNT;WNT-T CELLHedgehog;Axon guidance;Focal adhesion;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;Insulin_Receptor;Melanogenesis;Alzheimer's disease;Pathways in cancer;Colorectal cancer;Endometrial cancer;Prostate cancer;Basal cell carcinoma; |
| 功能 | catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,enzyme regulation:Inhibited when phosphorylated by AKT1.,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.,PTM:Phosphorylated by AKT1 and ILK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer (By similarity). Interacts with CABYR, MUC1, NIN and PRUNE.,tissue specificity:Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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