| 别名 | CTIP2;RIT1 |
| 基因名称 | BCL11B |
| 蛋白名称 | B-cell lymphoma/leukemia 11B (BCL-11B) (B-cell CLL/lymphoma 11B) (COUP-TF-interacting protein 2) (Radiation-induced tumor suppressor gene 1 protein) (hRit1) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64919 |
| Human Swissprot No. | Q9C0K0 |
| Human Swissprot Link | https://www.uniprot.org/uniprotkb/Q9C0K0/entry |
| Mouse Swissprot No. | Q99PV8 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/Q99PV8 |
| 稀释度 | IHC-P 1:200-1000,WB 1:1000-5000,IF-P/IF-F/IF-ICC 1:200-1000,ELISA 1:5000-20000,IP 1:50-200 |
| 参考分子量 | 96kDa |
| 预测分子量 | 96kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | B-cell CLL/lymphoma 11B(BCL11B) Homo sapiens This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013], |
| 功能 | function:Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with TFCOUP1, SIRT1, ARP1 and EAR2.,tissue specificity:Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
周一至周日 8:00-18:00
