| 别名 | PHB;Prohibitin |
| 基因名称 | PHB |
| 蛋白名称 | Prohibitin |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5245 |
| Human Swissprot No. | P35232 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P35232/entry |
| Mouse Gene ID | 18673 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18673 |
| Mouse Swissprot No. | P67778 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P67778 |
| Rat Gene ID | 25344 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25344 |
| Rat Swissprot No. | P67779 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P67779 |
| 稀释度 | IHC-P 1:200-1000,WB 1:1000-5000,IF-P/IF-F/IF-ICC 1:200-1000,ELISA 1:5000-20000,IP 1:50-200 |
| 参考分子量 | 30kDa |
| 预测分子量 | 30kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | prohibitin(PHB) Homo sapiens This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
| 功能 | developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging.,disease:Mutated in sporadic breast cancer.,function:Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.,induction:Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.,similarity:Belongs to the prohibitin family.,subunit:Interacts with PHB2.,tissue specificity:Widely expressed in different tissues., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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