| 别名 | CDK2;CDKN2;Cyclin-dependent kinase 2;Cell division protein kinase 2;p33 protein kinase |
| 蛋白名称 | CDK2 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1017 |
| Human Swissprot No. | P24941 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P24941/entry |
| Mouse Gene ID | 12566 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12566 |
| Mouse Swissprot No. | P97377 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P97377 |
| Rat Swissprot No. | Q63699 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/Q63699 |
| 稀释度 | IHC-P 1:1000-1:4000,WB 1:1000-1:5000,IF-P/IF-F/IF-ICC 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| 参考分子量 | 34kDa |
| 预测分子量 | 34kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 序列 | Cyclin-dependent kinase 2 |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | cyclin dependent kinase 2(CDK2) Homo sapiens This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014], |
| 信号通路 | Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;p53;Progesterone-mediated oocyte maturation;Pathways in cancer;Prostate cancer;Small cell lung cancer; |
| 功能 | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it.,function:Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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