| 别名 | NQO1;DIA4;NMOR1;NAD(P)H dehydrogenase [quinone] 1;Azoreductase;DT-diaphorase;DTD;Menadione reductase;NAD(P)H:quinone oxidoreductase 1;Phylloquinone reductase;Quinone reductase 1;QR1 |
| 蛋白名称 | NQO1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1728 |
| Human Swissprot No. | P15559 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P15559/entry |
| Mouse Swissprot No. | Q64669 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/Q64669 |
| 稀释度 | IHC-P 1:200-1:1000,WB 1:1000-1:5000,IF-P/IF-F/IF-ICC 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| 参考分子量 | 31kDa |
| 预测分子量 | 31kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 序列 | NAD(P)H dehydrogenase [quinone] 1 |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| 功能 | catalytic activity:NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.,cofactor:FAD.,enzyme regulation:Inhibited by dicoumarol.,function:The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.,induction:By dioxin.,mass spectrometry: PubMed:11735396,miscellaneous:Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency.,polymorphism:The Ser-187 polymorphism may be linked to susceptibility to forms of cancers.,similarity:Belongs to the NAD(P)H dehydrogenase (quinone) family.,subunit:Homodimer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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