| 别名 | GLUL;GLNS;Glutamine synthetase;GS;Glutamate decarboxylase;Glutamate--ammonia ligase |
| 蛋白名称 | GLUL |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2752 |
| Human Swissprot No. | P15104 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P15104/entry |
| Mouse Gene ID | 14645 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14645 |
| Mouse Swissprot No. | P15105 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P15105 |
| Rat Gene ID | 24957 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24957 |
| Rat Swissprot No. | P09606 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P09606 |
| 稀释度 | IHC-P 1:1000-1:4000, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 42kDa |
| 预测分子量 | 42kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 序列 | Glutamine synthetase |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014], |
| 信号通路 | Alanine; aspartate and glutamate metabolism;Arginine and proline metabolism;Nitrogen metabolism; |
| 功能 | catalytic activity:ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.,disease:Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.,online information:Glutamine synthetase entry,similarity:Belongs to the glutamine synthetase family.,subunit:Homooctamer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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