| 别名 | Cytochrome c;CYC |
| 基因名称 | CYCS |
| 蛋白名称 | CYCS |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54205 |
| Human Swissprot No. | P99999 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P99999/entry |
| Mouse Gene ID | 13063 |
| Mouse Swissprot No. | P62897 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P62897 |
| Rat Swissprot No. | P62898 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/O54941P62898 |
| 稀释度 | IHC-P 1:1000-1:4000,WB 1:1000-1:5000,IF-P/IF-F/IF-ICC 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 |
| 参考分子量 | 14kDa |
| 预测分子量 | 12kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010], |
| 信号通路 | p53;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Alzheimer's disease;Parkinson's disease;Amyotrophic lateral sclerosis (ALS);Huntington's disease;Pathways in cancer;Colorectal cancer;Small cell lung cancer;Viral myocarditis; |
| 功能 | disease:Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) [MIM:612004]; also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.,function:Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.,function:Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.,online information:Life shuttle - Issue 76 of November 2006,PTM:Binds 1 heme group per subunit.,similarity:Belongs to the cytochrome c family., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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