| 别名 | MIF;GLIF;MMIF;Macrophage migration inhibitory factor;MIF;Glycosylation-inhibiting factor;GIF;L-dopachrome isomerase;L-dopachrome tautomerase;Phenylpyruvate tautomerase |
| 基因名称 | MIF |
| 蛋白名称 | Macrophage migration inhibitory factor |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4282 |
| Human Swissprot No. | P14174 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P14174/entry |
| Mouse Gene ID | 17319 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17319 |
| Mouse Swissprot No. | P34884 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P34884 |
| Rat Gene ID | 81683 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81683 |
| Rat Swissprot No. | P30904 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P30904 |
| 稀释度 | IHC-P 1:3000-1:10000, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 13kDa |
| 预测分子量 | 13kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008], |
| 信号通路 | Tyrosine metabolism;Phenylalanine metabolism; |
| 功能 | catalytic activity:Keto-phenylpyruvate = enol-phenylpyruvate.,disease:Genetic variations in MIF are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase.,similarity:Belongs to the MIF family.,subunit:Homotrimer. Interacts with COPS5 and BNIPL., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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