| 别名 | DDIT3 |
| 基因名称 | DDIT3 |
| 蛋白名称 | DDIT3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1649 |
| Human Swissprot No. | P35638 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P35638/entry |
| Mouse Swissprot No. | P35639 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P35639 |
| Rat Swissprot No. | Q62857 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/O54941Q62857 |
| 稀释度 | IHC-P 1:100-1:400, WB 1:1000-1:5000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000 |
| 参考分子量 | 30kDa |
| 预测分子量 | 19kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010], |
| 信号通路 | MAPK_ERK_Growth;MAPK_G_Protein; |
| 功能 | disease:A chromosomal aberration involving DDIT3 is found in a form of malignant myxoid liposarcoma [MIM:126337]. Translocation t(12;16)(q13;p11) with FUS.,function:Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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