| 别名 | TNF;TNFA;TNFSF2;Tumor necrosis factor;Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;TNFA;TNFSF2 |
| 基因名称 | TNF |
| 蛋白名称 | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-doma |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7124 |
| Human Swissprot No. | P01375 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P01375/entry |
| Mouse Gene ID | 21926 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21926 |
| Mouse Swissprot No. | P06804 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P06804 |
| Rat Gene ID | 24835 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24835 |
| Rat Swissprot No. | P16599 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P16599 |
| 稀释度 | IHC-P 1:2000-1:10000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 18kDa |
| 预测分子量 | 26kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008], |
| 信号通路 | MAPK_ERK_Growth;MAPK_G_Protein;Cytokine-cytokine receptor interaction;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;TGF-beta;Toll_Like;NOD-like receptor;RIG-I-like receptor;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;T_Cell_Receptor;Fc epsilon RI;Adipocytokine;Type II diabetes mellitus;Type I diabetes mellitus;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Asthma;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy; |
| 功能 | disease:Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition.,disease:Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,disease:Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis.,function:Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.,online information:The Singapore human mutation and polymorphism database,online information:Tumor necrosis factor alpha entry,PTM:O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.,PTM:The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
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