货号：GZ8038
PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Replication protein C;RP C;RP-C;RPC;Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine protein phosphatase 2A catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PPP2CB
| 别名 | PP2A A;PP2A alpha;PP2A B;PP2A beta;PP2A-alpha;PP2A-beta;PP2AA_HUMAN;PP2Aalpha;PP2AB_HUMAN;PP2Abeta;PP2Ac;PP2CA;PP2Calpha;PP2CB;PPP2CA;PPP2CB;Protein phosphatase 2 catalytic subunit alpha isoform;Protein phosphatase 2 catalytic subunit beta isoform;Protein phosphatase type 2A catalytic subunit;Replication protein C;RP C;RP-C;RPC;Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine protein phosphatase 2A catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PPP2CB |
| 基因名称 | PPP2CA |
| 蛋白名称 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;PP2A-beta;PP2A-alpha;Replication protein C;RP-C; |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5515 |
| Human Swissprot No. | P67775,P62714 |
| Human Swissprot Link | http://www.uniprot.org/uniprotkb/P67775/entry |
| Mouse Gene ID | 19052;19053 |
| Mouse Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19052 |
| Mouse Swissprot No. | P63330;P62715 |
| Mouse Swissprot Link | http://www.uniprot.org/uniprot/P63330 |
| Rat Gene ID | 24672;24673 |
| Rat Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24672 |
| Rat Swissprot No. | P63331;P62716 |
| Rat Swissprot Link | http://www.uniprot.org/uniprot/P63331 |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 36kDa |
| 预测分子量 | 36kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008], |
| 信号通路 | Oocyte meiosis;WNT;WNT-T CELLTGF-beta;Tight junction;Long-term depression; |
| 功能 | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
周一至周日 8:00-18:00
