| 别名 | Autophagy protein 5 (APG5-like;Apoptosis-specific protein);APG5L;ASP |
| 基因名称 | ATG5 |
| 蛋白名称 | ATG5 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9474 |
| Human Swissprot No. | Q9H1Y0 |
| Human Swissprot Link | https://www.uniprot.org/uniprotkb/Q9H1Y0/entry |
| Mouse Gene ID | 11793 |
| Mouse Gene Link | https://www.uniprot.org/uniprot/11793 |
| Mouse Swissprot No. | Q99J83 |
| Mouse Swissprot Link | https://www.uniprot.org/uniprotkb/Q99J83 |
| Rat Swissprot No. | Q3MQ06 |
| Rat Swissprot Link | https://www.uniprot.org/uniprotkb/Q3MQ06 |
| 稀释度 | IHC-P 1:200-1:1000, WB 1:2000-1:10000, IF-P/IF-F/IF-ICC 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200 |
| 参考分子量 | 55kDa |
| 预测分子量 | 33kDa |
| 运输及保存条件 | Biological ice bag transportation. Store at -20°C for at least 12 months(Do not lower than -25°C). Avoid freeze/thaw cycles |
| 宿主 | Rabbit |
| 同种型 | Monoclonal, rabbit, IgG, Kappa |
| 背景介绍 | The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015], |
| 功能 | function:May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.,function:Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.,induction:By apoptotic stimuli.,PTM:Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.,similarity:Belongs to the ATG5 family.,subcellular location:Colocalizes with nonmuscle actin.,tissue specificity:Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
周一至周日 8:00-18:00
